Crank

Crank is a 2006 American action film written and directed by Mark Neveldine and Brian Taylor and starring Jason Statham, Amy Smart and Jose Pablo Cantillo. English hitman Chev Chelios is based in Los Angeles, is poisoned by the mafia and must keep his adrenaline flowing constantly in order to keep himself alive, while he tries to track down the man who poisoned him. The title of the film comes from a slang word for methamphetamine.