Blue in the Face is a 1995 American comedy film directed by Wayne Wang and Paul Auster. It stars Harvey Keitel leading an ensemble cast, including Giancarlo Esposito, Roseanne Barr, Michael J. Fox, Lily Tomlin, Victor Argo, Mira Sorvino, Lou Reed, Keith David, Jim Jarmusch, Jared Harris, RuPaul, and Madonna.