Awakenings is a 1990 American drama film directed by Penny Marshall. It is written by Steven Zaillian, who based his screenplay on Oliver Sacks's 1973 memoir Awakenings. It tells the story of neurologist Dr. Malcolm Sayer, who is based on Sacks, who discovers the beneficial effects of the drug L-DOPA in 1969. He administers it to catatonic patients who survived the 1917–1928 epidemic of encephalitis lethargica. Leonard Lowe and the rest of the patients are awakened after decades and have to deal with a new life in a new time. Julie Kavner, Ruth Nelson, John Heard, Penelope Ann Miller, Peter Stormare, and Max von Sydow also star.